We would like to introduce you to the research about the effectiveness of chlorine dioxide against SARS Covid 19 and its variants:
Abstract:
This study investigates the efficiency of chlorine dioxide against the novel coronavirus- SARS-CoV-2 and its variants. The research explores the mechanism of action of chlorine dioxide on the virus, its inhibitory effect on the binding activity of the virus to ACE2 receptors, and its inactivation potential against the original strain and variants of SARS-CoV-2.
Introduction:
The novel coronavirus, SARS-CoV-2, has caused a global pandemic, necessitating the exploration of potential treatments and preventive measures. Chlorine dioxide is evaluated as a potential candidate due to its inhibitory effects on the virus's spike protein binding to ACE2 receptors.
Methods:
The study employed a series of experiments to evaluate the effectiveness of chlorine dioxide:
* Spike protein from the novel coronavirus and its variants was mixed with various concentrations of aqueous chlorine dioxide.
* ACE2 receptor protein was introduced to bind with the spike protein.
* Horseradish peroxidase (HRP)-labeled anti-ACE2 antibody and chemiluminescent substrates were added.
* Chemiluminescence was measured to determine the inhibitory effect of chlorine dioxide on the binding activity of the virus to ACE2 receptors.
Results:
The research yielded the following key findings:
* Chlorine dioxide exhibited a dose-dependent inhibitory effect on the binding activity of the spike protein to ACE2 receptors.
* The IC50 values for aqueous chlorine dioxide solution required for 50% binding inhibition were as follows:
Novel coronavirus IC50
Original (Wuhan) strain: 6.5 µmol/L (0.4 ppm)
Alpha (British) variant: 7.6 µmol/L (0.5 ppm)
Beta (South African) variant: 5.8 µmol/L (0.4 ppm)
Chlorine dioxide effectively inhibited the binding of the virus to ACE2 receptors in all tested strains and variants.
Mechanism of Action:
Chlorine dioxide is believed to inhibit novel coronavirus infection by acting on the spike protein of the virus, thereby preventing its binding to ACE2 receptors.
Inactivation of SARS-CoV-2 by Chlorine Dioxide:
* Chlorine dioxide at a concentration of 8 ppm inactivated the virus infectivity by 99.96% in 10 seconds.
* At a concentration of 80 ppm, the virus was inactivated to levels below detection within the same time frame.
Inactivation of SARS-CoV-2 Variants by Chlorine Dioxide:
* Chlorine dioxide at a concentration of 154 ppm effectively inactivated the virus infectivity of the original strain, alpha variant (lineage B.1.1.7), and gamma variant (lineage P.1) by >99.99% within 10 seconds.
Conclusion:
This research demonstrates that chlorine dioxide effectively inhibits the binding activity of SARS-CoV-2 and its variants to ACE2 receptors and has a high potential for inactivating the virus. Chlorine dioxide may hold promise as a preventive measure or treatment against SARS-CoV-2 and its variants. Further studies are warranted to explore its clinical applications.
The information is taken from the website www .seirogan .co .jp .
This article is for informational purposes only, and Stream does not encourage anyone to use unconventional methods for treating any diseases. It recommends that in the event of any illness, individuals should seek consultation with their doctor.
